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HIV-1 Tat and cocaine impact mitochondrial epigenetics: effects on DNA methylation

24 Oct 2020

Abstract excerpt

Human immunodeficiency virus (HIV) infection and the psychostimulant drug cocaine are known to induce epigenetic changes in DNA methylation that are linked with the severity of viral replication and disease progression, which impair neuronal functions. Increasing evidence suggests that changes in DNA methylation and hydroxymethylation occur in mitochondrial DNA (mtDNA) and represent mitochondrial genome...

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PMID: 33100130
DOI: 10.1080/15592294.2020.1834919

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