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Article

A Single-Cell Perspective on the Effects of Dopamine in the Regulation of HIV Latency Phenotypes in a Myeloid Cell Model.

Viruses - 25 Jun 2025

Basova Liana V, Lim Wei Ling, Delorme-Walker Violaine, Riley Tera, Au Kaylin, Lima Daniel Siqueira, Lusic Marina, Ellis Ronald J, Fox Howard S, Marcondes Maria Cecilia Garibaldi

Abstract excerpt

Psychostimulants such as methamphetamine (Meth) induce high dopamine (DA) levels in the brain, which can modify immune cells expressing DA receptors. This is relevant in conditions of infection with the human immunodeficiency virus (HIV), overlapping with substance use. However, the effects of DA on HIV latency phenotypes are largely unknown. We used single-cell methods and gene network computational analysis to...

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Identifiers

PMID: 40733513
DOI: 10.3390/v17070895
PMCID: PMC12299422

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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