Article
Muscle-type specific autophosphorylation of CaMKII isoforms after paced contractions.
BioMed research international - 1 Jan 2014
Eilers Wouter, Gevers Wouter, van Overbeek Daniëlle, de Haan Arnold, Jaspers Richard T, Hilbers Peter A, van Riel Natal, Flück Martin
Abstract excerpt
We explored to what extent isoforms of the regulator of excitation-contraction and excitation-transcription coupling, calcium/calmodulin protein kinase II (CaMKII) contribute to the specificity of myocellular calcium sensing between muscle types and whether concentration transients in its autophosphorylation can be simulated. CaMKII autophosphorylation at Thr287 was assessed in three muscle compartments of the...
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