Article

CaMKII oxidation is a performance/disease trade-off in vertebrate evolution

2019-09-12

Abstract excerpt

Reactive oxygen species (ROS) contribute to health and disease. CaMKII is a widely expressed enzyme whose activation by oxidation of regulatory domain methionines (ox-CaMKII) contributes to cardiovascular disease, asthma, and cancer. Here we integrate comparative genomic and experimental data to show that CaMKII activation by ROS arose more than half-a-billion years ago on the vertebrate stem lineage where it cons...

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Literature Corpus work: 51f4ce62-a63b-596c-89ca-82a8c4ae06f6
DOI: 10.1101/767525

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