Article

An <i>in silico</i> Cardiomyocyte Reveals the Impact of Changes in CAMKII Signalling on Cardiomyocyte Contraction Kinetics in Hypertrophic Cardiomyopathy

2023-05-14

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is characterised by asymmetric left ventricular hypertrophy, ventricular arrhythmias and cardiomyocyte dysfunction that may cause sudden death. HCM is associated with mutations in sarcomeric proteins and is usually transmitted as an autosomal-dominant trait. The aim of this in silico study was to assess the mechanisms that underlie the altered electrophysiological activity, contr...

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Literature Corpus work: 94573469-403f-54cf-8c6b-47f7ddc44dea
DOI: 10.1101/2023.05.11.540337

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An <i>in silico</i> Cardiomyocyte Reveals the Impact of Changes in CAMKII Signalling on Cardiomyocyte Contraction Kinetics in Hypertrophic CardiomyopathyDOI 10.1101/2023.05.11.540337Read

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