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Article

Integrated activity of PDZ protein complexes regulates epithelial polarity.

Nature cell biology - 1 Jan 2003

Bilder David, Schober Markus, Perrimon Norbert

Abstract excerpt

Polarized cells contain numerous membrane domains, but it is unclear how the formation of these domains is coordinated to create a single integrated cell architecture. Genetic screens of Drosophila melanogaster embryos have identified three complexes, each containing one of the PDZ domain proteins--Stardust (Sdt), Bazooka (Baz) and Scribble (Scrib)--that control epithelial polarity and formation of zonula...

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Source

Identifiers

PMID: 12510194
DOI: 10.1038/ncb897

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Integrated activity of PDZ protein complexes regulates epithelial polarity.PMID 12510194Read ↗

Localization of apical epithelial determinants by the basolateral PDZ protein Scribble.Semantic proximity Read ↗

The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors.Semantic proximity Read ↗

Polarity protein complex Scribble/Lgl/Dlg and epithelial cell barriers.Semantic proximity Read ↗

Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids.Semantic proximity Read ↗

Tight junction protein Par6 interacts with an evolutionarily conserved region in the amino terminus of PALS1/stardust.Semantic proximity Read ↗

Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble.Semantic proximity Read ↗

The F-box protein Slmb restricts the activity of aPKC to polarize epithelial cells.Semantic proximity Read ↗

Adherens junction-dependent and -independent steps in the establishment of epithelial cell polarity in Drosophila.Semantic proximity Read ↗

Domain-specific early and late function of Dpatj in Drosophila photoreceptor cells.Semantic proximity Read ↗

Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts.Semantic proximity Read ↗

Redundant regulation of localization and protein stability of DmPar3.Semantic proximity Read ↗

The Scribble module regulates retromer-dependent endocytic trafficking during epithelial polarization.Semantic proximity Read ↗

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