Article
Tau knockout exacerbates degeneration of parvalbumin-positive neurons in substantia nigra pars reticulata in Parkinson's disease-related α-synuclein A53T mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2020
Jiao Luyan, Zheng Meige, Duan Jinhai, Wu Ting, Li Zhao, Liu Lin, Xiang Xianhong, Tang Xiaolu, He Jinyang, Li Xingjian, Zhang Guofeng, Ding Jinhui, Cai Huaibin, Lin Xian
Abstract excerpt
α-Synuclein (α-syn)-induced neurotoxicity has been generally accepted as a key step in the pathogenesis of Parkinson's disease (PD). Microtubule-associated protein tau, which is considered second only to α-syn, has been repeatedly linked with PD in association studies. However, the underlying interaction between these two PD-related proteins in vivo remains unclear. To investigate how the expression of tau...
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