An energy-efficient gating mechanism in the acetylcholine receptor channel suggested by molecular and Brownian dynamics.

Abstract excerpt

Acetylcholine receptors mediate electrical signaling between nerve and muscle by opening and closing a transmembrane ion conductive pore. Molecular and Brownian dynamics simulations are used to shed light on the location and mechanism of the channel gate. Four separate 5 ns molecular dynamics simulations are carried out on the imaged structure of the channel, a hypothetical open structure with a slightly wider...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biophysics
• Share to Databases, Protein
• Share to Ion Transport