Article
The sodium channel isoform transition at developing nodes of Ranvier in the peripheral nervous system: dependence on a Genetic program and myelination-induced cluster formation.
The Journal of comparative neurology - 15 Dec 2014
Luo Songjiang, Jaegle Martine, Li Roy, Ehring George R, Meijer Dies, Levinson Simon R
Abstract excerpt
Among sodium channel isoforms, Nav 1.6 is selectively expressed at nodes of Ranvier in both the CNS and the PNS. However, non-Nav 1.6 isoforms such as Nav 1.2 are also present at the CNS nodes in early development but gradually diminish later. It has been proposed that myelination is part of a glia-neuron signaling mechanism that produces this change in nodal isoform expression. The present study used...
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