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Article

Analysis of Gpr126 function defines distinct mechanisms controlling the initiation and maturation of myelin.

Development (Cambridge, England) - 1 Aug 2013

Glenn Thomas D, Talbot William S

Abstract excerpt

In peripheral nerves, Schwann cells form the myelin sheath, which allows the efficient propagation of action potentials along axons. The transcription factor Krox20 regulates the initiation of myelination in Schwann cells and is also required to maintain mature myelin. The adhesion G protein-coupled receptor (GPCR) Gpr126 is essential for Schwann cells to initiate myelination, but previous studies have not...

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Identifiers

PMID: 23804499
DOI: 10.1242/dev.093401
PMCID: PMC3931731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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