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Article

alphaII-spectrin is essential for assembly of the nodes of Ranvier in myelinated axons.

Current biology : CB - 20 Mar 2007

Voas Matthew G, Lyons David A, Naylor Stephen G, Arana Naomi, Rasband Matthew N, Talbot William S

Abstract excerpt

Saltatory conduction in myelinated axons requires organization of the nodes of Ranvier, where voltage-gated sodium channels are prominently localized [1]. Previous results indicate that alphaII-spectrin, a component of the cortical cytoskeleton [2], is enriched at the paranodes [3, 4], which flank the node of Ranvier, but alphaII-spectrin's function has not been investigated. Starting with a genetic screen in...

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PMID: 17331725
DOI: 10.1016/j.cub.2007.01.071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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