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Article

Oxidization without substrate unfolding triggers proteolysis of the peroxide-sensor, PerR.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jan 2016

Ahn Bo-Eun, Baker Tania A

Abstract excerpt

Peroxide operon regulator (PerR) is a broadly conserved hydrogen peroxide sensor in bacteria, and oxidation of PerR at its regulatory metal-binding site is considered irreversible. Here, we tested whether this oxidation specifically targets PerR for proteolysis. We find that oxidizing conditions stimulate PerR degradation in vivo, and LonA is the principal AAA+ (ATPases associated with diverse cellular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26677871
DOI: 10.1073/pnas.1522687112
PMCID: PMC4711837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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