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Article

Protein Dynamics in the Reductive Activation of a B12-Containing Enzyme.

Biochemistry - 17 Oct 2017

Goetzl Sebastian, Teutloff Christian, Werther Tobias, Hennig Sandra E, Jeoung Jae-Hun, Bittl Robert, Dobbek Holger

Abstract excerpt

B12-dependent proteins are involved in methyl transfer reactions ranging from the biosynthesis of methionine in humans to the formation of acetyl-CoA in anaerobic bacteria. During their catalytic cycle, they undergo large conformational changes to interact with various proteins. Recently, the crystal structure of the B12-containing corrinoid iron-sulfur protein (CoFeSP) in complex with its reductive activator...

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PMID: 28949132
DOI: 10.1021/acs.biochem.7b00477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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