Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Catalytic efficiency of enzymes: a theoretical analysis.

Biochemistry - 26 Mar 2013

Hammes-Schiffer Sharon

Abstract excerpt

This brief review analyzes the underlying physical principles of enzyme catalysis, with an emphasis on the role of equilibrium enzyme motions and conformational sampling. The concepts are developed in the context of three representative systems, namely, dihydrofolate reductase, ketosteroid isomerase, and soybean lipoxygenase. All of these reactions involve hydrogen transfer, but many of the concepts discussed are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalysis
Share to Enzymes
Share to Hydrogen Bonding

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lipoxygenase

Share to Molecular Dynamics Simulation

Share to Static Electricity

Share to Steroid Isomerases

Share to Tetrahydrofolate Dehydrogenase

Source

Open in PubMed Open full text

Identifiers

PMID: 23240765
DOI: 10.1021/bi301515j
PMCID: PMC3619019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Catalytic efficiency of enzymes: a theoretical analysis.PMID 23240765Read ↗

Electric Fields and Enzyme Catalysis.Semantic proximity Read ↗

Valence bond and enzyme catalysis: a time to break down and a time to build up.Semantic proximity Read ↗

A new conceptual framework for enzyme catalysis. Hydrogen tunnelling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes.Semantic proximity Read ↗

Multiple intermediates, diverse conformations, and cooperative conformational changes underlie the catalytic hydride transfer reaction of dihydrofolate reductase.Semantic proximity Read ↗

Enzyme catalysis: a new definition accounting for noncovalent substrate- and product-like states.Semantic proximity Read ↗

A Critical Test of the Electrostatic Contribution to Catalysis with Noncanonical Amino Acids in Ketosteroid Isomerase.Semantic proximity Read ↗

Linking protein structure and dynamics to catalysis: the role of hydrogen tunnelling.Semantic proximity Read ↗

Evolutionary dynamics of enzymes.Semantic proximity Read ↗

Importance of protein dynamics during enzymatic C-H bond cleavage catalysis.Semantic proximity Read ↗

Role of conformational dynamics in the evolution of novel enzyme function.Semantic proximity Read ↗

Allostery and Evolution: A Molecular Journey Through the Structural and Dynamical Landscape of an Enzyme Super Family.Semantic proximity Read ↗

[Computational mutation analysis of enzymatic reaction].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.