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Article

Mapping protein-protein interactions by localized oxidation: consequences of the reach of hydroxyl radical.

Biochemistry - 2 Jun 2009

Cheal Sarah M, Ng Mindy, Barrios Brianda, Miao Zheng, Kalani Amir K, Meares Claude F

Abstract excerpt

Hydroxyl radicals generated from a variety of methods, including not only synchrotron radiation but also Fenton reactions involving chelated iron, have become an accepted macromolecular footprinting tool. Hydroxyl radicals react with proteins via multiple mechanisms that lead to both polypeptide backbone cleavage events and side chain modifications (e.g., hydroxylation and carbonyl formation). The use of...

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Identifiers

PMID: 19354299
DOI: 10.1021/bi900273j
PMCID: PMC2713361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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