Article
PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation.
Annals of neurology - 1 Sept 2014
Jun Gyungah, Asai Hirohide, Zeldich Ella, Drapeau Elodie, Chen CiDi, Chung Jaeyoon, Park Jong-Ho, Kim Sehwa, Haroutunian Vahram, Foroud Tatiana, Kuwano Ryozo, Haines Jonathan L, Pericak-Vance Margaret A, Schellenberg Gerard D, Lunetta Kathryn L, Kim Jong-Won, Buxbaum Joseph D, Mayeux Richard, Ikezu Tsuneya, Abraham Carmela R, Farrer Lindsay A
Abstract excerpt
OBJECTIVE: Much of the genetic basis for Alzheimer disease (AD) is unexplained. We sought to identify novel AD loci using a unique family-based approach that can detect robust associations with infrequent variants (minor allele frequency < 0.10). METHODS: We conducted a genome-wide association study in the Framingham Heart Study (discovery) and NIA-LOAD (National Institute on Aging-Late-Onset Alzheimer Disease)...
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