Article
PVT1 dependence in cancer with MYC copy-number increase.
Nature - 7 Aug 2014
Tseng Yuen-Yi, Moriarity Branden S, Gong Wuming, Akiyama Ryutaro, Tiwari Ashutosh, Kawakami Hiroko, Ronning Peter, Reuland Brian, Guenther Kacey, Beadnell Thomas C, Essig Jaclyn, Otto George M, O'Sullivan M Gerard, Largaespada David A, Schwertfeger Kathryn L, Marahrens York, Kawakami Yasuhiko, Bagchi Anindya
Abstract excerpt
'Gain' of supernumerary copies of the 8q24.21 chromosomal region has been shown to be common in many human cancers and is associated with poor prognosis. The well-characterized myelocytomatosis (MYC) oncogene resides in the 8q24.21 region and is consistently co-gained with an adjacent 'gene desert' of approximately 2 megabases that contains the long non-coding RNA gene PVT1, the CCDC26 gene candidate and the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.