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Article

Estimating heritability of drug-induced liver injury from common variants and implications for future study designs.

Scientific reports - 21 Jul 2014

Overby Casey Lynnette, Hripcsak George, Shen Yufeng

Abstract excerpt

Recent genome-wide association studies identified certain human leukocyote antigen (HLA) alleles as the major risk factors of drug-induced liver injuries (DILI). While these alleles often cause large relative risk, their predictive values are quite low due to low prevalence of idiosyncratic DILI. Finding additional risk factors is important for precision medicine. However, optimal design of further genetic...

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Identifiers

PMID: 25042059
DOI: 10.1038/srep05762
PMCID: PMC4104390

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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