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Article

Polymorphisms in folate-metabolizing enzymes and response to 5-fluorouracil among patients with stage II or III rectal cancer (INT-0144; SWOG 9304).

Cancer - 1 Nov 2014

Ulrich Cornelia M, Rankin Cathryn, Toriola Adetunji T, Makar Karen W, Altug-Teber Özge, Benedetti Jacqueline K, Holmes Rebecca S, Smalley Stephen R, Blanke Charles D, Lenz Heinz-Josef

Abstract excerpt

BACKGROUND: Recurrence and toxicity occur commonly among patients with rectal cancer who are treated with 5-fluorouracil (5-FU). The authors hypothesized that genetic variation in folate-metabolizing genes could play a role in interindividual variability. The objective of the current study was to evaluate the associations between genetic variants in folate-metabolizing genes and clinical outcomes among patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Glycine Hydroxymethyltransferase

Share to Methylenetetrahydrofolate Reductase (NADPH2)

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Source

Open in PubMed Open full text

Identifiers

PMID: 25041994
DOI: 10.1002/cncr.28830
PMCID: PMC4259283

Genes

MTHFR
DHFR
SHMT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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