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5‐Fluorouracil‐based chemotherapy for colorectal cancer and MTHFR/MTRR genotypes

30 Dec 2010

Abstract excerpt

Treatment with 5-fluorouracil (5-FU) is known to improve survival in various cancers. The largest impact of the drug has been reported in colorectal cancer [1]. Active metabolites of 5-FU disrupt both DNA and RNA synthesis through a mechanism involving the folate metabolic pathway [2–4]. The overall response rate to 5-FU in advanced colorectal cancer is limited to 10–15%. Although survival is reported to improve...

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PMID: 21204909
DOI: 10.1111/j.1365-2125.2010.03892.x

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