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Acute myeloid leukemia impairs natural killer cells through the formation of a deficient cytotoxic immunological synapse

15 Jul 2014

Abstract excerpt

Acute myeloid leukemia (AML) cells are killed by allogeneic NK cells. However, autologous NK cells from AML patients express decreased levels of activating receptors, and show reduced cytotoxicity. Here, we investigated how interactions between NK and AML cells might cause loss of NK-cell activity in patients. Our results show that AML cell lines and primary blasts alter the NK-cell phenotype, reducing their...

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PMID: 25041786
DOI: 10.1002/eji.201444500

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