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NKp46 Clusters at the Immune Synapse and Regulates NK Cell Polarization

25 Sept 2015

Abstract excerpt

Natural killer (NK) cells play an important role in first-line defense against tumor and virus-infected cells. The activity of NK cells is tightly regulated by a repertoire of cell surface expressed inhibitory and activating receptors. NKp46 is a major NK cell-activating receptor that is involved in the elimination of target cells. NK cells form different types of synapses that result in distinct functional...

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CAR-T cell therapy research
Immune Cell Function and Interaction
T-cell and B-cell Immunology

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PMID: 26441997
DOI: 10.3389/fimmu.2015.00495

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