Kinetics of Cytotoxic Lymphocytes Reconstitution after Induction Chemotherapy in Elderly AML Patients Reveals Progressive Recovery of Normal Phenotypic and Functional Features in NK Cells

Abstract excerpt

NK cells are defective in acute myeloid Leukemia (AML) at diagnosis. Here we studied the kinetic of expression of the major activating and inhibitory receptors of NK, CD8 T and γδ T cells in patients undergoing chemotherapy (CT) for the treatment of AML (n=29). We show that NK cells are the main affected population at diagnosis and that expression of activating receptors is partially restored within a few weeks...

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