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Article

Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance

26 Aug 2019

Abstract excerpt

Only a subset of cancer patients respond to T-cell checkpoint inhibitors, highlighting the need for alternative immunotherapeutics. We performed CRISPR-Cas9 screens in a leukemia cell line to identify perturbations that enhance natural killer effector functions. Our screens defined critical components of the tumor-immune synapse and highlighted the importance of cancer cell interferon-γ signaling in modulating NK...

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PMID: 31452512
DOI: 10.7554/elife.47362

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