Article

Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance

2019-04-02

Abstract excerpt

Only a subset of cancer patients respond to T-cell checkpoint inhibitors, highlighting the need for alternative immunotherapeutics. We performed CRISPR-Cas9 screens in a leukemia cell line to identify perturbations that enhance natural killer effector functions. Our screens defined critical components of the tumor-immune synapse and highlighted the importance of cancer cell interferon- γ signaling in modulating N...

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Identifiers and source

Literature Corpus work: 783e00d1-f459-5a2c-b627-ec12ea94e177
DOI: 10.1101/597567

Open publication

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