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Enhancement of natural killer cell effector functions against selected lymphoma and leukemia cell lines by dasatinib

15 Mar 2012

Abstract excerpt

As NK cell immunotherapy is still poorly successful, combinations with drugs enhancing NK cell activity are of major interest. NK large granular lymphocyte expansions associated with improved survival have been described under monotherapy with the Bcr-Abl/Src inhibitor dasatinib, which inhibits NK cell functions in vitro. As Src kinases play a major role in inhibitory and activating signaling pathways of NK...

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PMID: 22419518
DOI: 10.1002/ijc.27537

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