Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A

23 Apr 2014

Abstract excerpt

Lytic immune effector function depends upon directed secretion of cytolytic granules at the immunological synapse (IS) and requires dynamic rearrangement of filamentous (F)-actin. Coronin 1A (Coro1A) is the hematopoietic-specific member of the Coronin family of actin regulators that promote F-actin disassembly. Here, we show that Coro1A is required for natural killer (NK) cell cytotoxic function in two human NK...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to HIV Research and Treatment
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24760828
DOI: 10.1073/pnas.1314975111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1APMID 24760828Read ↗

Morphological profiling of human T and NK lymphocytes identifies actin-mediated control of the immunological synapseSemantic proximity Read ↗

The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency.Semantic proximity Read ↗

Emerging functions of cytoskeletal proteins in immune diseasesSemantic proximity Read ↗

NCKAP1L defects lead to a novel syndrome combining immunodeficiency, lymphoproliferation, and hyperinflammation.Semantic proximity Read ↗

Recurrent viral infections associated with a homozygous CORO1A mutation that disrupts oligomerization and cytoskeletal association.Semantic proximity Read ↗

The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation.Semantic proximity Read ↗

The Actin Regulators Involved in the Function and Related Diseases of LymphocytesSemantic proximity Read ↗

DOCK8 regulates a mechanosensitive actin redistribution that maintains immune cell cohesion and protects the nucleus during migrationSemantic proximity Read ↗

Actin Cytoskeleton Straddling the Immunological Synapse between Cytotoxic Lymphocytes and Cancer CellsSemantic proximity Read ↗

Actin dynamics regulation by TTC7A/PI4KIIIα limits DNA damage and cell death under confinement.Semantic proximity Read ↗

Arp2/3 complex-dependent actin regulation protects the survival of tissue-resident mast cellsSemantic proximity Read ↗

Deciphering actin remodelling in immune cells through the prism of actin-related inborn errors of immunity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.