Article
Peripheral blood T cells in acute myeloid leukemia (AML) patients at diagnosis have abnormal phenotype and genotype and form defective immune synapses with AML blasts.
Blood - 29 Oct 2009
Le Dieu Rifca, Taussig David C, Ramsay Alan G, Mitter Richard, Miraki-Moud Faridah, Fatah Rewas, Lee Abigail M, Lister T Andrew, Gribben John G
Abstract excerpt
Understanding how the immune system in patients with cancer interacts with malignant cells is critical for the development of successful immunotherapeutic strategies. We studied peripheral blood from newly diagnosed patients with acute myeloid leukemia (AML) to assess the impact of this disease on the patients' T cells. The absolute number of peripheral blood T cells is increased in AML compared with healthy...
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