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Article

Vectored Intracerebral Immunization with the Anti-Tau Monoclonal Antibody PHF1 Markedly Reduces Tau Pathology in Mutant Tau Transgenic Mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Dec 2016

Liu Wencheng, Zhao Lingzhi, Blackman Brittany, Parmar Mayur, Wong Man Ying, Woo Thomas, Yu Fangmin, Chiuchiolo Maria J, Sondhi Dolan, Kaminsky Stephen M, Crystal Ronald G, Paul Steven M

Abstract excerpt

Passive immunization with anti-tau monoclonal antibodies has been shown by several laboratories to reduce age-dependent tau pathology and neurodegeneration in mutant tau transgenic mice. These studies have used repeated high weekly doses of various tau antibodies administered systemically for several months and have reported reduced tau pathology of ∼40-50% in various brain regions. Here we show that direct...

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Identifiers

PMID: 27927959
DOI: 10.1523/JNEUROSCI.2016-16.2016
PMCID: PMC6601971

Genes

PHF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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