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Article

ADAM10 regulates Notch function in intestinal stem cells of mice.

Gastroenterology - 1 Oct 2014

Tsai Yu-Hwai, VanDussen Kelli L, Sawey Eric T, Wade Alex W, Kasper Chelsea, Rakshit Sabita, Bhatt Riha G, Stoeck Alex, Maillard Ivan, Crawford Howard C, Samuelson Linda C, Dempsey Peter J

Abstract excerpt

BACKGROUND & AIMS: A disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) is a cell surface sheddase that regulates physiologic processes, including Notch signaling. ADAM10 is expressed in all intestinal epithelial cell types, but the requirement for ADAM10 signaling in crypt homeostasis is not well defined. METHODS: We analyzed intestinal tissues from mice with constitutive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25038433
DOI: 10.1053/j.gastro.2014.07.003
PMCID: PMC4176890

Genes

ADAM10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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