Article
Requirement of Math1 for secretory cell lineage commitment in the mouse intestine.
Science (New York, N.Y.) - 7 Dec 2001
Yang Q, Bermingham N A, Finegold M J, Zoghbi H Y
Abstract excerpt
The mouse small intestinal epithelium consists of four principal cell types deriving from one multipotent stem cell: enterocytes, goblet, enteroendocrine, and Paneth cells. Previous studies showed that Math1, a basic helix-loop-helix (bHLH) transcription factor, is expressed in the gut. We find that loss of Math1 leads to depletion of goblet, enteroendocrine, and Paneth cells without affecting enterocytes....
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