Article

A non-catalytic function of a disintegrin and metalloprotease 10 determines hepatic progenitor cell fate

2024-08-14

Abstract excerpt

During chronic liver disease, hepatocytes may undergo proliferative arrest, leading to the activation, expansion and differentiation of hepatic progenitor cells (HPCs). Here we observe that expression of A Disintegrin And Metalloprotease (ADAM) 10 is increased in human and murine chronic liver disease correlating with HPC expansion. We report that proteolytic processing of ADAM10 by ADAM9 and generation of an ADAM...

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Identifiers and source

Literature Corpus work: 93fd0fbe-fad4-5029-add8-9e52516d56d8
DOI: 10.1101/2024.08.14.607697

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