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Article

Vangl-dependent planar cell polarity signalling is not required for neural crest migration in mammals.

Development (Cambridge, England) - 1 Aug 2014

Pryor Sophie E, Massa Valentina, Savery Dawn, Andre Philipp, Yang Yingzi, Greene Nicholas D E, Copp Andrew J

Abstract excerpt

The role of planar cell polarity (PCP) signalling in neural crest (NC) development is unclear. The PCP dependence of NC cell migration has been reported in Xenopus and zebrafish, but NC migration has not been studied in mammalian PCP mutants. Vangl2(Lp/Lp) mouse embryos lack PCP signalling and undergo almost complete failure of neural tube closure. Here we show, however, that NC specification, migration and...

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Identifiers

PMID: 25038043
DOI: 10.1242/dev.111427
PMCID: PMC4197537

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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