Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel measurement of allele discrimination for assessment of allele-specific silencing by RNA interference.

Molecular biology reports - 1 Nov 2014

Takahashi Masaki, Hohjoh Hirohiko

Abstract excerpt

Allele-specific silencing by RNA interference (ASP-RNAi) is an atypical RNAi that is capable of discriminating target alleles from non-target alleles, and may be therapeutically useful for specific inhibition of disease-causing alleles without affecting their corresponding normal alleles. However, it is difficult to design and select small interfering RNA (siRNAs) that confer ASP-RNAi. A major problem is that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Gene Silencing
Share to Genetic Engineering

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HeLa Cells

Share to Luciferases

Share to Models, Genetic

Share to RNA Interference

Share to RNA, Small Interfering

Source

Identifiers

PMID: 25037272
DOI: 10.1007/s11033-014-3586-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel measurement of allele discrimination for assessment of allele-specific silencing by RNA interference.PMID 25037272Read ↗

Allele-specific silencing by RNA interference.Semantic proximity Read ↗

ASPsiRNA: A Resource of ASP-siRNAs Having Therapeutic Potential for Human Genetic Disorders and Algorithm for Prediction of Their Inhibitory Efficacy.Semantic proximity Read ↗

Enhancement of allele discrimination by introduction of nucleotide mismatches into siRNA in allele-specific gene silencing by RNAi.Semantic proximity Read ↗

Comparing computational methods for identification of allele-specific expression based on next generation sequencing data.Semantic proximity Read ↗

Silencing unhealthy alleles naturally.Semantic proximity Read ↗

Profiling of mismatch discrimination in RNAi enabled rational design of allele-specific siRNAs.Semantic proximity Read ↗

Protein interactions: analysis using allele libraries.Semantic proximity Read ↗

A new analysis tool for individual-level allele frequency for genomic studies.Semantic proximity Read ↗

Sources of bias in measures of allele-specific expression derived from RNA-sequence data aligned to a single reference genome.Semantic proximity Read ↗

Therapy for dominant inherited diseases by allele-specific RNA interference: successes and pitfalls.Semantic proximity Read ↗

New RNAi strategy for selective suppression of a mutant allele in polyglutamine disease.Semantic proximity Read ↗

ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.