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Article

Enhancement of allele discrimination by introduction of nucleotide mismatches into siRNA in allele-specific gene silencing by RNAi.

PloS one - 21 May 2008

Ohnishi Yusuke, Tamura Yoshiko, Yoshida Mariko, Tokunaga Katsushi, Hohjoh Hirohiko

Abstract excerpt

Allele-specific gene silencing by RNA interference (RNAi) is therapeutically useful for specifically inhibiting the expression of disease-associated alleles without suppressing the expression of corresponding wild-type alleles. To realize such allele-specific RNAi (ASP-RNAi), the design and assessment of small interfering RNA (siRNA) duplexes conferring ASP-RNAi is vital; however, it is also difficult. In a...

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Identifiers

PMID: 18493311
DOI: 10.1371/journal.pone.0002248
PMCID: PMC2373929

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PRNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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