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Article

Allele-specific silencing by RNA interference.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2010

Hohjoh Hirohiko

Abstract excerpt

Allele-specific gene silencing by RNA interference (RNAi) is therapeutically useful for specifically inhibiting the expression of disease-associated alleles without suppressing the expression of corresponding wild-type alleles. To realize such allele-specific RNAi (ASP-RNAi), the design and assessment of small interfering RNA (siRNA) duplexes conferring ASP-RNAi is vital; however, it is also difficult. We have...

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PMID: 20217544
DOI: 10.1007/978-1-60761-588-0_4

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