Comparing computational methods for identification of allele-specific expression based on next generation sequencing data.

Abstract excerpt

Allele-specific expression (ASE) studies have wide-ranging implications for genome biology and medicine. Whole transcriptome RNA sequencing (RNA-Seq) has emerged as a genome-wide tool for identifying ASE, but suffers from mapping bias favoring reference alleles. Two categories of methods are adopted nowadays, to reduce the effect of mapping bias on ASE identification-normalizing RNA allelic ratio with the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Computer Simulation
• Share to False Negative Reactions