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Article

Silencing unhealthy alleles naturally.

Trends in biotechnology - 1 May 2003

Moss Eric G

Abstract excerpt

Recently, it has been reported that small interfering RNAs can silence mutant alleles of genes while not affecting wild-type alleles. This high specificity should also limit off-target effects when these molecules are used in drug-target validation or as therapeutics. Small RNA technology is both extremely versatile, because virtually any expressed gene can be inhibited, and effective, because it exploits natural...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12727375
DOI: 10.1016/S0167-7799(03)00088-X

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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