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Article

Sources of bias in measures of allele-specific expression derived from RNA-sequence data aligned to a single reference genome.

BMC genomics - 7 Aug 2013

Stevenson Kraig R, Coolon Joseph D, Wittkopp Patricia J

Abstract excerpt

BACKGROUND: RNA-seq can be used to measure allele-specific expression (ASE) by assigning sequence reads to individual alleles; however, relative ASE is systematically biased when sequence reads are aligned to a single reference genome. Aligning sequence reads to both parental genomes can eliminat...

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PMID: 23919664
DOI: 10.1186/1471-2164-14-536
PMCID: PMC3751238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-23919664-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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