Article
A new analysis tool for individual-level allele frequency for genomic studies.
BMC genomics - 5 Jul 2010
Yang Hsin-Chou, Lin Hsin-Chi, Huang Mei-Chu, Li Ling-Hui, Pan Wen-Harn, Wu Jer-Yuarn, Chen Yuan-Tsong
Abstract excerpt
BACKGROUND: Allele frequency is one of the most important population indices and has been broadly applied to genetic/genomic studies. Estimation of allele frequency using genotypes is convenient but may lose data information and be sensitive to genotyping errors. RESULTS: This study utilizes a unified intensity-measuring approach to estimating individual-level allele frequencies for 1,104 and 1,270 samples...
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