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Article

Therapy for dominant inherited diseases by allele-specific RNA interference: successes and pitfalls.

Current gene therapy - 1 Jan 2015

Trochet Delphine, Prudhon Bernard, Vassilopoulos Stéphane, Bitoun Marc

Abstract excerpt

RNA interference (RNAi) is a conserved mechanism for post-transcriptional gene silencing mediated by messenger RNA (mRNA) degradation. RNAi is commonly induced by synthetic siRNA or shRNA which recognizes the targeted mRNA by base pairing and leads to target-mRNA degradation. RNAi may discriminat...

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Identifiers

PMID: 26264709
DOI: 10.2174/1566523215666150812115730

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26264709-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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