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Article

Comparison of methods to account for relatedness in genome-wide association studies with family-based data.

PLoS genetics - 1 Jul 2014

Eu-Ahsunthornwattana Jakris, Miller E Nancy, Fakiola Michaela, Jeronimo Selma M B, Blackwell Jenefer M, Cordell Heather J

Abstract excerpt

Approaches based on linear mixed models (LMMs) have recently gained popularity for modelling population substructure and relatedness in genome-wide association studies. In the last few years, a bewildering variety of different LMM methods/software packages have been developed, but it is not always clear how (or indeed whether) any newly-proposed method differs from previously-proposed implementations. Here we...

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PMID: 25033443
DOI: 10.1371/journal.pgen.1004445
PMCID: PMC4102448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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