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Article

The Quantitative-MFG Test: A Linear Mixed Effect Model to Detect Maternal-Offspring Gene Interactions.

Annals of human genetics - 1 Jan 2016

Clark Michelle M, Blangero John, Dyer Thomas D, Sobel Eric M, Sinsheimer Janet S

Abstract excerpt

Maternal-offspring gene interactions, aka maternal-fetal genotype (MFG) incompatibilities, are neglected in complex diseases and quantitative trait studies. They are implicated in birth to adult onset diseases but there are limited ways to investigate their influence on quantitative traits. We present the quantitative-MFG (QMFG) test, a linear mixed model where maternal and offspring genotypes are fixed effects...

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Identifiers

PMID: 26567478
DOI: 10.1111/ahg.12137
PMCID: PMC4715557

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