Article
Local genealogies in a linear mixed model for genome-wide association mapping in complex pedigreed populations.
PloS one - 1 Jan 2011
Sahana Goutam, Mailund Thomas, Lund Mogens Sandø, Guldbrandtsen Bernt
Abstract excerpt
INTRODUCTION: The state-of-the-art for dealing with multiple levels of relationship among the samples in genome-wide association studies (GWAS) is unified mixed model analysis (MMA). This approach is very flexible, can be applied to both family-based and population-based samples, and can be extended to incorporate other effects in a straightforward and rigorous fashion. Here, we present a complementary approach,...
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