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Article

A genealogical estimate of genetic relationships.

American journal of human genetics - 5 May 2022

Fan Caoqi, Mancuso Nicholas, Chiang Charleston W K

Abstract excerpt

The application of genetic relationships among individuals, characterized by a genetic relationship matrix (GRM), has far-reaching effects in human genetics. However, the current standard to calculate the GRM treats linked markers as independent and does not explicitly model the underlying genealogical history of the study sample. Here, we propose a coalescent-informed framework, namely the expected GRM (eGRM),...

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Identifiers

PMID: 35417677
DOI: 10.1016/j.ajhg.2022.03.016
PMCID: PMC9118131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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