Article

A genealogical estimate of genetic relationships

2021-08-18

Abstract excerpt

The application of genetic relationships among individuals, characterized by a genetic relationship matrix (GRM), has far-reaching effects in human genetics. However, the current standard to calculate the GRM generally does not take advantage of linkage information and does not reflect the underlying genealogical history of the study sample. Here, we propose a coalescent-informed framework to infer the expected re...

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Literature Corpus work: 46fb42ca-0fea-520c-974e-83412b8fc7a9
DOI: 10.1101/2021.08.18.456747

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