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Exploring the genetic basis of coronary artery disease using functional genomics.

Atherosclerosis - 1 Jun 2023

López Rodríguez Maykel, Arasu Uma Thanigai, Kaikkonen Minna U

Abstract excerpt

Genome-wide Association Studies (GWAS) have identified more than 300 loci associated with coronary artery disease (CAD), defining the genetic risk map of the disease. However, the translation of the association signals into biological-pathophysiological mechanisms constitute a major challenge. Through a group of examples of studies focused on CAD, we discuss the rationale, basic principles and outcomes of the...

Topics

Humans
Coronary Artery Disease
Genome-Wide Association Study
Genomics
Risk Factors
Polymorphism, Single Nucleotide
Genetic Predisposition to Disease

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36801133
DOI: 10.1016/j.atherosclerosis.2023.01.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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