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Article

Reduced endoplasmic reticulum stress-induced apoptosis and impaired unfolded protein response in TRPC3-deficient M1 macrophages.

American journal of physiology. Cell physiology - 15 Sept 2014

Solanki Sumeet, Dube Prabhatchandra R, Tano Jean-Yves, Birnbaumer Lutz, Vazquez Guillermo

Abstract excerpt

Endoplasmic reticulum (ER) stress is a prominent mechanism of macrophage apoptosis in advanced atherosclerotic lesions. Recent studies from our laboratory showed that advanced atherosclerotic plaques in Apoe(-/-) mice with bone marrow deficiency of the calcium-permeable channel Transient Receptor Potential Canonical 3 (TRPC3) are characterized by reduced areas of necrosis and fewer apoptotic macrophages than...

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Source

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Identifiers

PMID: 25031020
DOI: 10.1152/ajpcell.00369.2013
PMCID: PMC4166736

Genes

TRPC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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