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Article

Truncated thioredoxin (Trx-80) promotes pro-inflammatory macrophages of the M1 phenotype and enhances atherosclerosis.

Journal of cellular physiology - 1 Jul 2013

Mahmood Dler Faieeq Darweesh, Abderrazak Amna, Couchie Dominique, Lunov Oleg, Diderot Vimala, Syrovets Tatiana, Slimane Mohamed-Naceur, Gosselet Fabien, Simmet Thomas, Rouis Mustapha, El Hadri Khadija

Abstract excerpt

Vascular cells are particularly susceptible to oxidative stress that is believed to play a key role in the pathogenesis of cardiovascular disorders. Thioredoxin-1 (Trx-1) is an oxidative stress-limiting protein with anti-inflammatory and anti-apoptotic properties. In contrast, its truncated form (Trx-80) exerts pro-inflammatory effects. Here we analyzed whether Trx-80 might exert atherogenic effects by promoting...

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PMID: 23335265
DOI: 10.1002/jcp.24319

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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