Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

M2 macrophages exhibit higher sensitivity to oxLDL-induced lipotoxicity than other monocyte/macrophage subtypes.

Lipids in health and disease - 6 Dec 2011

Isa Suleiman A, Ruffino José S, Ahluwalia Maninder, Thomas Andrew W, Morris Keith, Webb Richard

Abstract excerpt

BACKGROUND: In obesity, phenotypic switches occur in macrophage populations such that the predominantly M2-polarised anti-inflammatory state seen in lean individuals changes to a predominantly M1-polarised pro-inflammatory state in those who are obese. However, the mechanisms by which these phenotypic shifts occur have not yet been fully elucidated. RESULTS: The effects of oxLDL (1-40 μg/ml; 24 h) on several...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoplasmic Reticulum Chaperone BiP
Share to Endoplasmic Reticulum Stress

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mannose-Binding Lectins

Share to Mannose Receptor

Share to Primary Cell Culture

Share to Regulatory Factor X Transcription Factors

Share to Transcription Factor CHOP

Share to X-Box Binding Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 22146099
DOI: 10.1186/1476-511X-10-229
PMCID: PMC3281809

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

M2 macrophages exhibit higher sensitivity to oxLDL-induced lipotoxicity than other monocyte/macrophage subtypes.PMID 22146099Read ↗

Macrophage Polarization in Obesity and Type 2 Diabetes: Weighing Down Our Understanding of Macrophage Function?Semantic proximity Read ↗

Palmitate differentially regulates the polarization of differentiating and differentiated macrophages.Semantic proximity Read ↗

Treatment with sitagliptin exacerbates the M2 phenotype in macrophages in vitro.Semantic proximity Read ↗

M1/M2 macrophage polarization in human obese adipose tissue.Semantic proximity Read ↗

Impaired alternative macrophage differentiation of peripheral blood mononuclear cells from obese subjects.Semantic proximity Read ↗

Unbalanced M1/M2 Phenotype of Peripheral Blood Monocytes in Obese Diabetic PatientsSemantic proximity Read ↗

Oxidized LDL Modify the Human Adipocyte Phenotype to an Insulin Resistant, Proinflamatory and Proapoptotic Profile.Semantic proximity Read ↗

IL-4 polarized human macrophage exosomes control cardiometabolic inflammation and diabetes in obesitySemantic proximity Read ↗

In vitro phenotypic effects of Lipoxin A4 on M1 and M2 polarized macrophages derived from THP-1.Semantic proximity Read ↗

Polarizing properties of lipoxin A4 on THP-1 macrophages in vitroSemantic proximity Read ↗

The effect of oxidized phospholipids on phenotypic polarization and function of macrophages.Semantic proximity Read ↗

Endoplasmic reticulum stress controls M2 macrophage differentiation and foam cell formation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.